Otto pilot: The Washington Times' Joseph Szadkowski talks with Stan Lee about the origin of Dr. Octopus:

"The easiest way to get a supervillain is the accident in the lab. I remembered the pictures of scientists working with radioactive material, and to keep them from becoming radioactive, they had the arms that went through the glass shelf that they can manipulate the stuff.

"So I had a guy have the accident, and four arms became grafted to him. Of course, I named him Dr. Otto Octavius, and those arms would make him look like an octopus."